From the village of Zwieselstein in the Ötztal Valley through Timmelsjoch to Alto Adige. E5 runs through Moso along the Val Passiria to the Pfandler alpine hut on Mount Hirzer to Merano 2000, along the ridge and through the Salto plateau to the village of San Genesio.  The San Genesio cable car takes hikers down to the valley of Bolzano.

E5 southern route
Stage 1 – from Zwieselstein to Moso
Stage 2 – from Moso to the Pfandler alpine hut
Stage 3 – from the Pfandler alpine hut to Refuge Merano
Stage 4- from Refuge Merano to Bolzano

It is possible to walk from San Genesio to Bolzano along route n. 1 (an ascent of approx. 750 m and 1.5 hours' walking time)

Parking is available at Zwieselstein in the Ötztal Valley

Along the Val Passiria through Timmelsjoch mountain pass in the Ötztal Valley to Zwieselstein.